Specificity and reversibility of chemotactic deactivation of human monocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-159588
DOI to cite this document:: 10.5283/epub.15958

Falk, Werner ; Leonard, E.J.

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Date of publication of this fulltext: 20 Jul 2010 06:14

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Abstract

The chemotactic deactivation of human monocytes was studied to provide insight into the mechanism of chemotaxis. Deactivation was dependent on the dose of chemoattractant and time of incubation. A concentration in the cell suspension of 10(-8) M N-formylmethionylleucyl phenylalanine (FMLP) for 45 min at 37 degrees C led to 60% suppression of the subsequent specific chemotactic response. Higher ...