Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor

URN to cite this document:: urn:nbn:de:bvb:355-epub-159616
DOI to cite this document:: 10.5283/epub.15961

Männel, D. N. ; Falk, Werner ; Meltzer, M. S.

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Date of publication of this fulltext: 20 Jul 2010 06:12

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Abstract

Mouse peritoneal macrophages activated for tumor cytotoxicity by any of several in vivo or in vitro treatments released a soluble cytotoxin into culture fluids only after exposure to small amounts of bacterial lipopolysaccharides. This cytotoxic factor was physicochemically similar to the cytotoxic factor (tumor necrosis factor) in sera of BCG-infected mice injected with lipopolysaccharide. A ...