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Inhibition of chemotaxis by S-3-deazaadenosylhomocysteine in a mouse macrophage cell line

URN to cite this document:
urn:nbn:de:bvb:355-epub-159621
Aksamit, R.R. ; Falk, Werner ; Cantoni, G.L.
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Date of publication of this fulltext: 20 Jul 2010 09:15


Abstract

Chemotaxis by a macrophage cell line, RAW264, is specifically inhibited by the intracellular accumulation of 3-deazaadenosylhomocysteine (3-deaza-AdoHcy). Intracellular accumulation of 3-deaza-AdoHcy is the result of incubation of the cells with 3-deazaadenosine, a compound that can function both as a substrate and as an inhibitor of adenosylhomocysteine (AdoHcy) hydrolase. Accumulation of AdoHcy ...

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