Inhibition of chemotaxis by S-3-deazaadenosylhomocysteine in a mouse macrophage cell line

URN to cite this document:: urn:nbn:de:bvb:355-epub-159621
DOI to cite this document:: 10.5283/epub.15962

Aksamit, R. R. ; Falk, Werner ; Cantoni, G. L.

Preview

PDF
(641kB)

Date of publication of this fulltext: 20 Jul 2010 09:15

Alternative links to fulltext:Pubmed

Details

Preview

Export bibliographical data

Abstract

Chemotaxis by a macrophage cell line, RAW264, is specifically inhibited by the intracellular accumulation of 3-deazaadenosylhomocysteine (3-deaza-AdoHcy). Intracellular accumulation of 3-deaza-AdoHcy is the result of incubation of the cells with 3-deazaadenosine, a compound that can function both as a substrate and as an inhibitor of adenosylhomocysteine (AdoHcy) hydrolase. Accumulation of AdoHcy ...