Activation of cytotoxic T lymphocytes requires at least two spleen cell-derived helper factors besides interleukin 2

URN to cite this document:: urn:nbn:de:bvb:355-epub-159711
DOI to cite this document:: 10.5283/epub.15971

Falk, Werner ; Männel, D. N. ; Dröge, W.

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Date of publication of this fulltext: 21 Jul 2010 05:05

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Abstract

The dependency of induction of T cell cytotoxicity on lymphokines was studied. 1 X 10(5) nylon wool-purified thymic lymphocytes or 10(4) spleen cells were cultured with TNP-haptenated syngeneic UV-irradiated spleen cells in the presence of a variety of lymphokine preparations. Concanavalin A-induced spleen cell supernatants mediated strong cytotoxic responses in this system. Three other ...