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Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1

Falk, Werner, Männel, D.N., Katzer, B., Kaltmann, B., Krammer, P.H., Diamantstein, T. and Dröge, W. (1985) Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1. Journal of immunology (Baltimore, Md. : 1950) 135 (2), pp. 1160-1164.

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Date of publication of this fulltext: 21 Jul 2010 05:11

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Abstract

We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day culture. The expression of cytotoxicity was dependent on the addition of TCF1 derived from the T cell hybridoma K15. TCF1 also induced proliferation ...

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Item type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3924999PubMed ID
Classification:
NotationType
AnimalsMESH
Antibodies, Monoclonal/physiologyMESH
Cell DifferentiationMESH
Cytotoxicity, ImmunologicMESH
Interleukin-1/physiologyMESH
Interleukin-2/physiologyMESH
Lymphocyte ActivationMESH
Lymphokines/physiologyMESH
MaleMESH
MiceMESH
Mice, Inbred C3HMESH
Receptors, Immunologic/immunologyMESH
Receptors, Interleukin-2MESH
Stem Cells/immunologyMESH
Suppressor Factors, ImmunologicMESH
T-Lymphocytes, Cytotoxic/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15976
Owner only: item control page

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