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Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2

URN to cite this document:
Männel, D.N. ; Mizel, S.B. ; Diamantstein, T. ; Falk, Werner
Date of publication of this fulltext: 21 Jul 2010 09:23


Thymocyte cultures from C3H/HeJ mice were stimulated for proliferative responses with purified preparations of interleukin 1 (IL 1) and interleukin 2 (IL 2). Synergistic responses were obtained in the absence of mitogen. In the presence of excess IL 2, the thymocyte proliferation response was strictly dependent on the amount of IL 1 in the cultures. Antibodies to IL 1 inhibited the response in a ...


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