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Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal

Wolf, M., Falk, Werner, Männel, D.N. and Dröge, W. (1985) Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal. Cellular immunology 90 (1), pp. 190-195.

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Date of publication of this fulltext: 21 Jul 2010 09:23

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Abstract

In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optimal stimulation (5 micrograms/ml concanavalin A) but does inhibit at suboptimal ...

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Item type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3871360PubMed ID
Classification:
NotationType
AnimalsMESH
Concanavalin A/pharmacologyMESH
Depression, ChemicalMESH
DinoprostoneMESH
Dose-Response Relationship, DrugMESH
Interleukin-2/biosynthesisMESH
MaleMESH
MiceMESH
Prostaglandins E/pharmacologyMESH
Spleen/cytologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:15984
Owner only: item control page

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