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Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal

URN to cite this document:
urn:nbn:de:bvb:355-epub-159849
Wolf, M. ; Falk, Werner ; Männel, D.N. ; Dröge, W.
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Date of publication of this fulltext: 21 Jul 2010 09:23


Abstract

In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optimal stimulation (5 micrograms/ml concanavalin A) but does inhibit at suboptimal ...

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