Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-159950

Debatin, K.M., Woodroofe, C., Lahm, H., Fischer, J., Falk, Werner, Brandeis, W.E. und Krammer, P.H. (1989) Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 3 (8), S. 566-571.

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Zusammenfassung

Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...

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