Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2

URN to cite this document:

urn:nbn:de:bvb:355-epub-159950

Debatin, K.M. ; Woodroofe, C. ; Lahm, H. ; Fischer, J. ; Falk, Werner ; Brandeis, W.E. ; Krammer, P.H.

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Date of publication of this fulltext: 22 Jul 2010 05:00

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Details

Item type:	Article
Date:	1989
Institutions:	Medicine > Lehrstuhl für Innere Medizin I
Identification Number:	Value Type 2787451 PubMed ID
Classification:	Notation Type Adolescent MESH Child MESH Child, Preschool MESH Female MESH Humans MESH Interleukin-2/physiology MESH Leukemia-Lymphoma, Adult T-Cell/pathology MESH Lymphocyte Activation MESH Lymphoma, Non-Hodgkin/pathology MESH Male MESH Phenotype MESH Receptors, Interleukin-2/analysis MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	15995

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Abstract

Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...

Abstract

Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this study we use malignant T cells from nine patients with the clinical diagnosis of T-ALL or T-NHL and did not detect IL-2 dependent growth under conditions in which normal T cells responded to IL-2. IL-2 receptors comparable in numbers to activated T cells were found on T-ALL/T-NHL cells stimulated with PHA and PMA. However, binding studies using radiolabeled IL-2 indicated that the receptors present on malignant T cells were not able to bind to IL-2 with high affinity. Therefore, if IL-2 is involved in the proliferation of malignant T cells, its mechanism of growth regulation may be different from the one for normal T cells. Alternatively, IL-2 may not play a role in the regulation of growth of malignant T cells in vitro.

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Metadata last modified: 03 Jun 2018 14:47

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