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Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2

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Debatin, K. M. ; Woodroofe, C. ; Lahm, H. ; Fischer, J. ; Falk, Werner ; Brandeis, W. E. ; Krammer, P. H.
Date of publication of this fulltext: 22 Jul 2010 05:00


Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...


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