Debatin, K.M., Woodroofe, C., Lahm, H., Fischer, J., Falk, Werner, Brandeis, W.E. and Krammer, P.H.
(1989)
Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 3 (8), pp. 566-571.
Date of publication of this fulltext: 22 Jul 2010 05:00at PubMed
Abstract
Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...
Abstract
Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this study we use malignant T cells from nine patients with the clinical diagnosis of T-ALL or T-NHL and did not detect IL-2 dependent growth under conditions in which normal T cells responded to IL-2. IL-2 receptors comparable in numbers to activated T cells were found on T-ALL/T-NHL cells stimulated with PHA and PMA. However, binding studies using radiolabeled IL-2 indicated that the receptors present on malignant T cells were not able to bind to IL-2 with high affinity. Therefore, if IL-2 is involved in the proliferation of malignant T cells, its mechanism of growth regulation may be different from the one for normal T cells. Alternatively, IL-2 may not play a role in the regulation of growth of malignant T cells in vitro.
Export bibliographical data
| Item type: | Article |
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| Date: | 1989 |
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| Institutions: | Medicine > Lehrstuhl für Innere Medizin I |
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| Identification Number: | | Value | Type |
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| 2787451 | PubMed ID |
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| Classification: | | Notation | Type |
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| Adolescent | MESH | | Child | MESH | | Child, Preschool | MESH | | Female | MESH | | Humans | MESH | | Interleukin-2/physiology | MESH | | Leukemia-Lymphoma, Adult T-Cell/pathology | MESH | | Lymphocyte Activation | MESH | | Lymphoma, Non-Hodgkin/pathology | MESH | | Male | MESH | | Phenotype | MESH | | Receptors, Interleukin-2/analysis | MESH |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 15995 |
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