Debatin, K.M., Woodroofe, C., Lahm, H., Fischer, J., Falk, Werner, Brandeis, W.E. und Krammer, P.H.
(1989)
Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 3 (8), S. 566-571.
Veröffentlichungsdatum dieses Volltextes: 22 Jul 2010 05:00Zum PubMed-Eintrag dieses Artikels
Zusammenfassung
Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this ...
Zusammenfassung
Binding of interleukin-2 (IL-2) to high affinity receptors on activated normal T cells was shown to be the essential step in induction of proliferation of such cells. The finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells. In this study we use malignant T cells from nine patients with the clinical diagnosis of T-ALL or T-NHL and did not detect IL-2 dependent growth under conditions in which normal T cells responded to IL-2. IL-2 receptors comparable in numbers to activated T cells were found on T-ALL/T-NHL cells stimulated with PHA and PMA. However, binding studies using radiolabeled IL-2 indicated that the receptors present on malignant T cells were not able to bind to IL-2 with high affinity. Therefore, if IL-2 is involved in the proliferation of malignant T cells, its mechanism of growth regulation may be different from the one for normal T cells. Alternatively, IL-2 may not play a role in the regulation of growth of malignant T cells in vitro.
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| Dokumentenart: | Artikel |
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| Datum: | 1989 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
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| Identifikationsnummer: | |
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| Klassifikation: | | Notation | Art |
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| Adolescent | MESH | | Child | MESH | | Child, Preschool | MESH | | Female | MESH | | Humans | MESH | | Interleukin-2/physiology | MESH | | Leukemia-Lymphoma, Adult T-Cell/pathology | MESH | | Lymphocyte Activation | MESH | | Lymphoma, Non-Hodgkin/pathology | MESH | | Male | MESH | | Phenotype | MESH | | Receptors, Interleukin-2/analysis | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
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| Dokumenten-ID: | 15995 |
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