IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-159966
DOI to cite this document:: 10.5283/epub.15996

Falk, Werner ; Männel, D. N. ; Darjes, H. ; Krammer, P. H.

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Date of publication of this fulltext: 22 Jul 2010 05:00

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Abstract

We investigated the role of cytokines for the growth of CD4-8-thymocytes (double negative thymocytes) (DNT) in vitro and found that IL-1-induced IL-2-dependent proliferation of only the IL-2R-positive DNT subpopulation. The presence of IL-1 during the first 18 h of culture was sufficient for an optimal response and suggested that IL-1 induced DNT differentiation. We could indeed show by RNA dot ...