Falk, Werner, Hoegen, I. von und Krammer, P.H.
(1989)
Activation of T cells by interleukin 1 involves internalization of interleukin 1.
Lymphokine research 8 (3), S. 263-268.
Veröffentlichungsdatum dieses Volltextes: 22 Jul 2010 04:59Zum PubMed-Eintrag dieses Artikels
Zusammenfassung
The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression. The events that follow binding of IL-1 to its receptor are not known. We found that in a purified T cell population (comprising the Lyt2- and L3T4- T cells) IL-1 in the absence of antigen or mitogen induced strong proliferation and de novo expression of IL-2R light chain mRNA. This ...
Zusammenfassung
The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression. The events that follow binding of IL-1 to its receptor are not known. We found that in a purified T cell population (comprising the Lyt2- and L3T4- T cells) IL-1 in the absence of antigen or mitogen induced strong proliferation and de novo expression of IL-2R light chain mRNA. This was accompanied by high affinity IL-2 binding. Production of IL-2 or IL-2 mRNA was not detected under these conditions. As a model system for IL-1 action two EL4 subclones were isolated. EL4 5D3 responded to IL-1 by augmentation of PMA induced IL-2 secretion and IL-2R expression. EL4D6/76 bound IL-1 with the same affinity but did not respond. We found that this line was unable to internalize surface bound IL-1. The finding suggests that in T cells internalization of IL-1 is required for its activity.
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| Dokumentenart: | Artikel |
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| Datum: | 1989 |
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| Institutionen: | Medizin > Lehrstuhl für Innere Medizin I |
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| Identifikationsnummer: | |
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| Klassifikation: | | Notation | Art |
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| Animals | MESH | | Biological Transport, Active | MESH | | Clone Cells/metabolism | MESH | | Interleukin-1/pharmacology | MESH | | Interleukin-2/biosynthesis | MESH | | Lymphocyte Activation | MESH | | Mice | MESH | | RNA, Messenger/metabolism | MESH | | Receptors, Interleukin-2/genetics | MESH | | T-Lymphocytes/metabolism | MESH | | Tetradecanoylphorbol Acetate/pharmacology | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
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| Dokumenten-ID: | 15997 |
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