Activation of T cells by interleukin 1 involves internalization of interleukin 1

URN to cite this document:: urn:nbn:de:bvb:355-epub-159970

Falk, Werner ; Hoegen, I. von ; Krammer, P.H.

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Date of publication of this fulltext: 22 Jul 2010 04:59

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Abstract

The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression. The events that follow binding of IL-1 to its receptor are not known. We found that in a purified T cell population (comprising the Lyt2- and L3T4- T cells) IL-1 in the absence of antigen or mitogen induced strong proliferation and de novo expression of IL-2R light chain mRNA. This ...