Optimal induction of tumor necrosis factor production in human monocytes requires complete S-form lipopolysaccharide

URN to cite this document:: urn:nbn:de:bvb:355-epub-160064
DOI to cite this document:: 10.5283/epub.16006

Männel, D. N. ; Falk, Werner

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Date of publication of this fulltext: 08 Sep 2010 05:26

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Abstract

Optimal activation of human monocytes in vitro for the biosynthesis of tumor necrosis factor was achieved only with complete S-form lipopolysaccharide. Endotoxin preparations with shorter carbohydrate chains or the lipid A component of lipopolysaccharide were not able to induce release of comparable amounts of tumor necrosis factor by monocytes under the conditions described. The same differences ...