Monoclonal antibody-mediated tumor regression by induction of apoptosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-160075
DOI to cite this document:: 10.5283/epub.16007

Trauth, B. C. ; Klas, C. ; Peters, A. M. ; Matzku, S. ; Möller, P. ; Falk, Werner ; Debatin, K. M. ; Krammer, P. H.

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Date of publication of this fulltext: 08 Sep 2010 05:25

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Abstract

To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised against the human B lymphoblast cell line SKW6.4. One monoclonal antibody, anti-APO-1, reacted with a 52-kilodalton antigen (APO-1) on a set of activated human lymphocytes, on malignant human lymphocyte lines, and on some patient-derived leukemic cells. Nanogram ...