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Monoclonal antibody-mediated tumor regression by induction of apoptosis

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Trauth, B. C. ; Klas, C. ; Peters, A. M. ; Matzku, S. ; Möller, P. ; Falk, Werner ; Debatin, K. M. ; Krammer, P. H.
Date of publication of this fulltext: 08 Sep 2010 05:25


To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised against the human B lymphoblast cell line SKW6.4. One monoclonal antibody, anti-APO-1, reacted with a 52-kilodalton antigen (APO-1) on a set of activated human lymphocytes, on malignant human lymphocyte lines, and on some patient-derived leukemic cells. Nanogram ...


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