Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-164676
DOI to cite this document:: 10.5283/epub.16467

Echtenacher, B. ; Falk, Werner ; Männel, D. N. ; Krammer, P. H.

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Date of publication of this fulltext: 08 Sep 2010 05:24

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Abstract

By intrasplenic immunization we raised a rat mAb (mAb V1q; IgG2a, kappa) with a potent neutralizing activity against natural mouse TNF (1 microgram/ml mAb V1q/100 U/ml TNF). mAb V1q was used to study the role of endogenous TNF in experimental peritonitis induced by sublethal cecal ligation and puncture. mAb V1q persisted for over 5 days in the serum of mice injected with 100 micrograms of the ...