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Autocrine growth factors secreted by the malignant human B-cell-line BJAB are distinct from other known cytokines

Lahm, H. ; Fischer, J. R. ; Reichert, Y. ; Hederer, R. ; Falk, Werner ; Debatin, K. M. ; Krammer, P. H.



Abstract

BJAB, a EBV-negative Burkitt-like lymphoma, did not grow under suboptimal culture conditions in low concentrations of serum unless appropriate cytokines were added. A subclone of BJAB, Clone 13, however, could be kept in long-term culture under such conditions without added cytokines. This suggested that growth of BJAB-Clone 13 was supported by autocrine growth factors (AGF). In fact, the ...

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