Inhibition of murine cytotoxic T cell responses by progesterone

URN to cite this document:: urn:nbn:de:bvb:355-epub-164708
DOI to cite this document:: 10.5283/epub.16470

Männel, D. N. ; Falk, Werner ; Yron, I.

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Date of publication of this fulltext: 08 Sep 2010 05:22

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Abstract

In the present study we evaluated the effect of sex hormone on the generation of murine cytotoxic T cell responses. We show that the in vitro CTL response was strongly inhibited by progesterone but not by E1, E2 or testosterone. Our experiments attempting to understand the mechanism of the hormone action on CTL development have revealed that the ability of the cells to generate helper signals was ...