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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

Franken, S. M. ; Scheidig, A. J. ; Krengel, U. ; Rensland, H. ; Lautwein, A. ; Geyer, M. ; Scheffzek, K. ; Goody, R. S. ; Kalbitzer, Hans Robert ; Pai, E. F. ; Wittinghofer, A.


The three-dimensional structures and biochemical properties of two mutants of the G-domain (residues 1-166) of p21H-ras, p21 (G12D) and p21 (G12P), have been determined in the triphosphate-bound form using guanosine 5'-(beta,gamma-imido)triphosphate (GppNHp). They correspond to the most frequent oncogenic and the only nononcogenic mutation of Gly-12, respectively. The G12D mutation is the only ...


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