Enhancement of experimental metastasis by tumor necrosis factor

URN to cite this document:: urn:nbn:de:bvb:355-epub-164975
DOI to cite this document:: 10.5283/epub.16497

Orosz, P. ; Echtenacher, Bernd ; Falk, Werner ; Rüschoff, J. ; Weber, D. ; Männel, Daniela N.

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Date of publication of this fulltext: 08 Sep 2010 05:14

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Abstract

The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model. A single intraperitoneal injection of recombinant human (rh) TNF or recombinant mouse (rm) TNF into mice 5 h before intravenous inoculation of methylcholanthrene-induced fibrosarcoma cells (CFS1) induced a significant enhancement of the number of ...