Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1

URN to cite this document:: urn:nbn:de:bvb:355-epub-165003
DOI to cite this document:: 10.5283/epub.16500

Falk, Werner ; Stricker, K. ; Praast, G. ; Tsukitani, Y. ; Krammer, P. H. ; Stoeck, M.

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Date of publication of this fulltext: 08 Sep 2010 05:12

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Abstract

Interleukin-1 (IL-1) has potent immunoregulatory and inflammatory functions. Its activity is mediated by an 80-kDa receptor on the cell surface and leads to activation of other genes. The underlying molecular events are largely unknown. We investigated the role of phosphatases in activation of the IL-2 gene in EL4 thymoma cells. We found that the protein phosphatase PP1 and PP2A inhibitor okadaic ...