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Mechanisms involved in metastasis enhanced by inflammatory mediators

URN to cite this document:
urn:nbn:de:bvb:355-epub-165011
Männel, D. N. ; Orosz, P. ; Hafner, M. ; Falk, Werner
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Date of publication of this fulltext: 08 Sep 2010 05:11


Abstract

The enhancement of tumor metastasis by concurrent inflammatory processes is mainly due to the cytokines TNF and IL-1. In the case of TNF this effect is not restricted to metastasis models as measured by in vivo colony formation but also found in experimental model systems of spontaneous metastasis. Direct effects on the tumor cells or interference with the host NK cell system did not seem to ...

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