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A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease

Freund, J. ; Kellner, R. ; Konvalinka, J. ; Wolber, V. ; Kräusslich, H. G. ; Kalbitzer, Hans Robert



Abstract

Negative factor (Nef) protein from human immunodeficiency virus type 1 (HIV-1) is cleaved into two well-defined domains by the HIV-1-encoded protease. The cleavage site is located between Trp57 and Leu58 and is well conserved. The two domains are stable in the presence of protease for more than 48 h. The C-terminal core domain contains a well-conserved well-folded region. The cleavage releases ...

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