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Specific cleavage sites of Nef proteins from human immunodeficiency virus types 1 and 2 for the viral proteases

Schorr, J. ; Kellner, R. ; Fackler, O. ; Freund, J. ; Konvalinka, J. ; Kienzle, N. ; Kräusslich, H. G. ; Mueller-Lantzsch, N. ; Kalbitzer, Hans Robert



Abstract

Human immunodeficiency virus type 2 (HIV-2) Nef is proteolytically cleaved by the HIV-2-encoded protease. The proteolysis is not influenced by the absence or presence of the N-terminal myristoylation. The main cleavage site is located between residues 39 and 40, suggesting a protease recognition sequence, GGEY-SQFQ. As observed previously for Nef protein from HIV-1, a large, stable core domain ...

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