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Structure of the inactivating gate from the Shaker voltage gated K⁺ channel analyzed by NMR spectroscopy

Schott, M. K. ; Antz, C. ; Frank, R. ; Ruppersberg, J. P. ; Kalbitzer, Hans Robert



Abstract

Rapid inactivation of voltage-gated K+ (Kv) channels is mediated by an N-terminal domain (inactivating ball domain) which blocks the open channel from the cytoplasmic side. Inactivating ball domains of various Kv channels are also biologically active when synthesized separately and added as a peptide to the solution. Synthetic inactivating ball domains from different Kv channels with hardly any ...

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