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Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

Linnemann, T. ; Geyer, M. ; Jaitner, B. K. ; Block, C. ; Kalbitzer, Hans Robert ; Wittinghofer, A. ; Herrmann, C.



Abstract

Cellular signaling downstream of Ras is highly diversified and may involve many different effector molecules. A potential candidate is AF6 which was originally identified as a fusion to ALL-1 in acute myeloid leukemia. In the present work the interaction between Ras and AF6 is characterized and compared with other effectors. The binding characteristics are quite similar to Raf and RalGEF, i.e. ...

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