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Control of K⁺ channel gating by protein phosphorylation: structural switches of the inactivation gate

Antz, C. ; Bauer, T. ; Kalbacher, H. ; Frank, R. ; Covarrubias, M. ; Kalbitzer, Hans Robert ; Ruppersberg, J. P. ; Baukrowitz, T. ; Fakler, B.



Abstract

Fast N-type inactivation of voltage-dependent potassium (Kv) channels controls membrane excitability and signal propagation in central neurons and occurs by a 'ball-and-chain'-type mechanism. In this mechanism an N-terminal protein domain (inactivation gate) occludes the pore from the cytoplasmic side. In Kv3.4 channels, inactivation is not fixed but is dynamically regulated by protein ...

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