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Structural and biochemical analysis of Ras-effector signaling via RalGDS

Vetter, I. R. ; Linnemann, T. ; Wohlgemuth, S. ; Geyer, M. ; Kalbitzer, Hans Robert ; Herrmann, C. ; Wittinghofer, A.


The structure of the complex of Ras with the Ras-binding domain of its effector RalGDS (RGS-RBD), the first genuine Ras-effector complex, has been solved by X-ray crystallography. As with the Rap-RafRBD complex (Nasser et al., 1995), the interaction is via an inter-protein beta-sheet between the switch I region of Ras and the second strand of the RGS-RBD sheet, but the details of the interactions ...


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