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Molecular alignment of proteins in bicellar solutions: quantitative evaluation of effects induced in 2D COSY spectra

Brunner, E. ; Ogle, J. ; Wenzler, M. ; Kalbitzer, Hans Robert



Abstract

Partial molecular alignment leads to an incomplete averaging of anisotropic magnetic interactions such as magnetic dipole interaction or chemical shift anisotropy. In the present contribution we quantitatively describe and evaluate the effects induced by the addition of magnetically oriented lipid bicelles in homonuclear two-dimensional (2D) NMR correlation (COSY) spectra of proteins. It is shown ...

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