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Structure of the metal-water complex in Ras x GDP studied by high-field EPR spectroscopy and ³¹P NMR spectroscopy

Rohrer, M. ; Prisner, T. F. ; Brügmann, O. ; Käss, H. ; Spoerner, M. ; Wittinghofer, A. ; Kalbitzer, Hans Robert



Abstract

The small GTPase Ras plays a key role as a molecular switch in the intercellular signal transduction. On Mg(2+) --> Mn(2+) substituted samples, the first ligand sphere of the metal ion in the inactive, GDP-bound Ras has been studied by continuous wave EPR at 94 GHz (W-band). Via replacement of normal water with (17)O-enriched water, the (17)O--(55)Mn superhyperfine coupling was used to determine ...

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