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Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, Hans Robert and Wittinghofer, A. (2001) Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proceedings of the National Academy of Sciences of the United States of America: PNAS 98 (9), pp. 4944-4949.

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Abstract

We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a reduced affinity to Ras effector proteins without Thr-35 being involved in any interaction. The ...

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Item type:Article
Date:2001
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
2196171PubMed ID
10.1073/pnas.081441398DOI
Classification:
NotationType
Amino Acid Substitution/geneticsMESH
Binding SitesMESH
Conserved Sequence/geneticsMESH
Crystallography, X-RayMESH
Guanylyl Imidodiphosphate/metabolismMESH
HumansMESH
IsomerismMESH
KineticsMESH
LigandsMESH
Magnesium/metabolismMESH
Magnetic Resonance SpectroscopyMESH
Models, MolecularMESH
Mutation/geneticsMESH
Protein BindingMESH
Protein Structure, TertiaryMESH
Proto-Oncogene Proteins p21(ras)/metabolismMESH
Threonine/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:16577
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