Go to content
UR Home

Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M. ; Herrmann, C. ; Vetter, I. R. ; Kalbitzer, Hans Robert ; Wittinghofer, A.



Abstract

We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a reduced affinity to Ras effector proteins without Thr-35 being involved in any interaction. The ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons