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Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M. ; Herrmann, C. ; Vetter, I. R. ; Kalbitzer, Hans Robert ; Wittinghofer, A.


We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a reduced affinity to Ras effector proteins without Thr-35 being involved in any interaction. The ...


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