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Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPγNH₂ and GTPγF

Stumber, Michael ; Herrmann, Christian ; Wohlgemuth, Sabine ; Kalbitzer, Hans Robert ; Jahn, Werner ; Geyer, Matthias



Abstract

Guanosine triphosphate nucleotide analogues such as GppNHp (also named GMPPNP) or GTPgammaS are widely used to stabilize rapidly hydrolyzing protein-nucleotide complexes and to investigate biochemical reaction pathways. Here we describe the chemical synthesis of guanosine 5'-O-(gamma-amidotriphosphate) (GTPgammaNH(2)) and a new synthesis of guanosine 5'-O-(gamma-fluorotriphosphate) (GTPgammaF). ...

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