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Role of entropy in protein thermostability: folding kinetics of a hyperthermophilic cold shock protein at high temperatures using ¹⁹F NMR

Schuler, Benjamin ; Kremer, Werner ; Kalbitzer, Hans Robert ; Jaenicke, Rainer


We used (19)F NMR to extend the temperature range accessible to detailed kinetic and equilibrium studies of a hyperthermophilic protein. Employing an optimized incorporation strategy, the small cold shock protein from the bacterium Thermotoga maritima (TmCsp) was labeled with 5-fluorotryptophan. Although chaotropically induced unfolding transitions revealed a significant decrease in the ...


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