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Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4

Wissmann, Ralph ; Bildl, Wolfgang ; Oliver, Dominik ; Beyermann, Michael ; Kalbitzer, Hans Robert ; Bentrop, Detlef ; Fakler, Bernd


Cumulative inactivation of voltage-gated (Kv) K(+) channels shapes the presynaptic action potential and determines timing and strength of synaptic transmission. Kv1.4 channels exhibit rapid "ball-and-chain"-type inactivation gating. Different from all other Kvalpha subunits, Kv1.4 harbors two inactivation domains at its N terminus. Here we report the solution structure and function of this ...


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