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Solution structure of the matrix attachment region-binding domain of chicken MeCP2

Heitmann, Björn ; Maurer, Till ; Weitzel, Joachim M. ; Strätling, Wolf H. ; Kalbitzer, Hans Robert ; Brunner, Eike


Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional protein involved in chromatin organization and silencing of methylated DNA. MAR-BD, a 125-amino-acid residue domain of chicken MeCP2 (cMeCP2, originally named ARBP), is the minimal protein fragment required to recognize MAR elements and mouse satellite DNA. Here we report the solution structure of MAR-BD as determined by multidimensional ...


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