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Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity

Kachel, Norman ; Erdmann, Kai Sven ; Kremer, Werner ; Wolff, Peter ; Gronwald, Wolfram ; Heumann, Rolf ; Kalbitzer, Hans Robert



Abstract

Two versions of the PDZ2 domain of the protein tyrosine phosphatase PTP-Bas/human PTP-BL are generated by alternative splicing. The domains differ by the insertion of five amino acid residues and their affinity to the tumour suppressor protein APC. Whereas PDZ2a is able to bind APC in the nanomolar range, PDZ2b shows no apparent interaction with APC. Here the solution structure of the splicing ...

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