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The central domain of the matrix protein of HIV-1: influence on protein structure and virus infectivity

Ellenrieder, Anja-Daniela ; Kremer, Werner ; Kattenbeck, Bernhard ; Hantschel, Oliver ; Horn, Gudrun ; Kalbitzer, Hans Robert ; Modrow, Susanne


The central region of the matrix protein p17 of HIV-1 is known to be essential during virus assembly. We substituted alanines for amino acid triplets in this region of p17 (amino acid residues 47 to 55: NPG LLE TSE). Introduction of the respective mutations into the gag-coding sequence of HI-proviruses and subsequent transfection into Cos-7 cells led to particle production and release. Exchange ...


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