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The use of high-sensitivity sapphire cells in high pressure NMR spectroscopy and its application to proteins

Kremer, Werner ; Arnold, M. R. ; Kachel, N. ; Kalbitzer, Hans Robert


The application of high pressure in bioscience and biotechnology has become an intriguing field in un/refolding and misfolding processes of proteins. NMR spectroscopy is the only generally applicable method to monitor pressure-induced structural changes at the atomic level in solution. Up to now the application of most of the multidimensional NMR experiments is impossible due to the restricted ...


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