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Perturbation of the conformational equilibria in Ras by selective mutations as studied by ³¹P NMR spectroscopy

Spoerner, Michael ; Wittinghofer, Alfred ; Kalbitzer, Hans Robert



Abstract

Ras regulates a variety of different signal transduction pathways acting as molecular switch. It was shown by liquid and solid-state (31)P NMR spectroscopy that Ras exists in the guanosine-5'-(beta,gamma-imido)triphosphate bound form in at least two conformational states interconverting in millisecond time scale. The relative population between the two conformational states affects drastically ...

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