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Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH₂p: implications for the interaction with effector proteins

Spoerner, Michael ; Nuehs, Andrea ; Ganser, Petra ; Herrmann, Christian ; Wittinghofer, Alfred ; Kalbitzer, Hans Robert



Abstract

The guanine nucleotide-binding protein Ras occurs in solution in two different states, state 1 and state 2, when the GTP analogue GppNHp is bound to the active center as detected by (31)P NMR spectroscopy. Here we show that Ras(wt).Mg(2+).GppCH(2)p also exists in two conformational states in dynamic equilibrium. The activation enthalpy DeltaH(++)(12) and the activation entropy DeltaS(++)(12) for ...

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