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Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPγS

Spoerner, Michael ; Nuehs, Andrea ; Herrmann, Christian ; Steiner, Guido ; Kalbitzer, Hans Robert



Abstract

The guanine nucleotide-binding protein Ras occurs in solution in two different conformational states, state 1 and state 2 with an equilibrium constant K(12) of 2.0, when the GTP analogue guanosine-5'-(beta,gamma-imido)triphosphate or guanosine-5'-(beta,gamma-methyleno)triphosphate is bound to the active centre. State 2 is assumed to represent a strong binding state for effectors with a ...

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