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Species-specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy

Kremer, Werner ; Kachel, Norman ; Kuwata, Kazuo ; Akasaka, Kazuyuki ; Kalbitzer, Hans Robert



Abstract

Human (huPrP) and Syrian hamster (ShaPrP) prion proteins have barriers for mutual infectivity, although they fold into almost an identical structure. The pressure responses of huPrP and ShaPrP characterized by high pressure NMR spectroscopy show differences in their excited states, as monitored by pressure-induced chemical shifts and intensity changes of individual residues in the (15)N/(1)H HSQC ...

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