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The role of TNF receptor type 2 on myeloid cells in sepsis - functional analysis

URN to cite this document:
urn:nbn:de:bvb:355-epub-170908
Polz, Johannes
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Dissertation - Johannes Polz
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Date of publication of this fulltext: 27 Oct 2010 07:25


Abstract (English)

Sepsis is a serious medical condition that is characterized by a whole-body inflammatory state and the presence of a known or suspected infection Dr. Theo Sterns reported that TNFR2 deficient mice were protected from a secondary infection during the phase of sepsis that is usually characterized as sepsis-induced immunosuppression The results shown and discussed in this work reveal several ...

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Translation of the abstract (German)

Das Krankheitsbild der Sepsis geht im Zusammenhang mit Sekundärinfektionen häufig mit hoher Morbidität und Mortalität einher und ist daher ein wichtiges Themengebiet der angewandten biomedizinischen Forschung. Dr. Theo Sterns hat 2005 in seiner Doktorarbeit beschrieben, dass die Abwesenheit von TNF-Rezeptor Typ-2 (TNFR2) im Mausmodell für Sepsis, der CLP-induzierten Peritonitis, einen Schutz vor ...

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