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The role of TNF receptor type 2 on myeloid cells in sepsis - functional analysis

Polz, Johannes (2010) The role of TNF receptor type 2 on myeloid cells in sepsis - functional analysis. PhD, Universität Regensburg.

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Dissertation - Johannes Polz
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Date of publication of this fulltext: 27 Oct 2010 07:25

Abstract (English)

Sepsis is a serious medical condition that is characterized by a whole-body inflammatory state and the presence of a known or suspected infection Dr. Theo Sterns reported that TNFR2 deficient mice were protected from a secondary infection during the phase of sepsis that is usually characterized as sepsis-induced immunosuppression The results shown and discussed in this work reveal several ...


Translation of the abstract (German)

Das Krankheitsbild der Sepsis geht im Zusammenhang mit Sekundärinfektionen häufig mit hoher Morbidität und Mortalität einher und ist daher ein wichtiges Themengebiet der angewandten biomedizinischen Forschung. Dr. Theo Sterns hat 2005 in seiner Doktorarbeit beschrieben, dass die Abwesenheit von TNF-Rezeptor Typ-2 (TNFR2) im Mausmodell für Sepsis, der CLP-induzierten Peritonitis, einen Schutz vor ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:27 October 2010
Referee:Prof. Dr. Daniela Männel and PD Dr. Thomas Langmann
Date of exam:30 September 2010
Institutions:Medicine > Lehrstuhl für Immunologie
Biology, Preclinical Medicine
Interdisciplinary Subject Network:Not selected
Keywords:Tumor necrosis factor (TNF), TNF receptor type 2 (TNFR2), inflammation, sepsis, myeloid derived suppressor cells (MDSC), nitric oxygen synthetase type 2 (iNOS), arginase type 1 (Arg1), nitric oxygen (NO), bone marrow derived dendritic cells (BMDC), myeloid cells, macrophages
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17090
Owner only: item control page


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