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In vivo skin penetration studies of chamomile flavones

Merfort, Irmgard ; Heilmann, Jörg ; Hagedorn-Leweke, Ursula ; Lippold, B. C.


In vivo skin penetration studies of the Chamomile flavones apigenin, luteolin and apigenin 7-O-beta -glucoside were carried out with nine healthy, female volunteers. During seven h, the decline of flavonoid concn. in a satd. aq. alc. soln. filled in glass application chambers were repeatedly measured by spectrophotometry at fixed time periods. The max. fluxes were calcd. From the graph of the ...


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