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Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs

Merfort, Irmgard ; Heilmann, Jörg ; Weiss, Manfred ; Pietta, Piergiorgio ; Gardana, Claudio



Abstract

3,4-Dihydroxyphenylacetic acid (I), 3-hydroxyphenylacetic acid (II), and 3-(4-hydroxyphenyl)propionic acid (III), metabolites which arise from quercetin glycosides, resp., from flavones and probably from procyanidins by the human intestinal microflora, have been tested for their effects on oxygen radical prodn. by human PNMs stimulated with FMLP or opsonized zymosan. Oxygen radicals were detected ...

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