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Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune

Jaki, B., Orjala, J., Heilmann, Jörg, Linden, A., Vogler, B. and Sticher, O. (2000) Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune. Journal of natural products 63 (3), pp. 339-343.

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Abstract

Five novel extracellular metabolites with an unprecedented diterpenoid skeleton and designated comnostins A-D (I-IV, resp.) and E have been isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune by means of bioguided isolation. The structures were detd. by spectroscopic methods, mainly NMR and mass spectrometry. The relative stereochem. of I was confirmed by ...

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Item type:Article
Date:2000
Additional Information (public):CAN 132:276414 10-1 Microbial, Algal, and Fungal Biochemistry 263842-17-7P (Comnostin B) Role: AGR (Agricultural use), BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune); 263842-16-6P (Comnostin A); 263842-18-8P (Comnostin C); 263842-19-9P (Comnostin D); 263842-20-2P (Comnostin E) Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation), USES (Uses) (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2000:111827Other
Keywords:Animal cell line (Caco-2 cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Animal cell line (KB cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Antitumor agents (carcinoma cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) New natural products (comnostins A-E (diterpenoids) Biomphalaria glabrata Molluscicides (cytotoxic and molluscicidal activities of comnostin B from Nostoc commune) Antibiotics Configuration (novel extracellular diterpenoids with biol. activity from the cyanobacterium Nostoc commune) Diterpenes Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence Crystal structure (of comnostin A) Molecular structure (of comnostins A-E (diterpenoids) cyanobacteria bioactive diterpenoid comnostin bioactive diterpenoid Nostoc antibiotic comnostin Nostoc molluscicide comnostin B Nostoc cytotoxicity comnostin B Nostoc crystal structure comnostin A
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17186
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