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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Journal of natural products | ||||
| Verlag: | American Chemical Society | ||||
| Band: | 63 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Seitenbereich: | S. 104-108 | ||||
| Datum: | 2000 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 132:134789 11-1 Plant Biochemistry 256471-46-2P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ialibinone A; phloroglucinol derivs. from Hypericum papuanum); 256471-47-3P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ialibinone B; phloroglucinol derivs. from Hypericum papuanum); 256471-48-4P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ialibinone C; phloroglucinol derivs. from Hypericum papuanum); 256471-49-5P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ialibinone D; phloroglucinol derivs. from Hypericum papuanum); 256471-50-8P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (ialibinone E; phloroglucinol derivs. from Hypericum papuanum) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Bacillus cereus Micrococcus luteus Staphylococcus epidermidis (antibacterial activity of phloroglucinol derivs. from Hypericum papuanum) Molecular structure (of ialibinone A phloroglucinol derivs. from Hypericum papuanum) Molecular structure (of ialibinone B phloroglucinol derivs. from Hypericum papuanum) Molecular structure (of ialibinone C phloroglucinol derivs. from Hypericum papuanum) Molecular structure (of ialibinone D phloroglucinol derivs. from Hypericum papuanum) Molecular structure (of ialibinone E phloroglucinol derivs. from Hypericum papuanum) Antibacterial agents New natural products St.-John's-wort (phloroglucinol derivs. from Hypericum papuanum) phloroglucinol deriv Hypericum | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17190 |
Zusammenfassung
Bioactivity-guided fractionation of the petroleum ether ext. of the aerial parts of Hypericum papuanum led to the isolation of five new tricyclic phloroglucinol derivs. On the basis of extensive 1D and 2D NMR expts. as well as MS studies, their structures were elucidated as the C-3 epimers of 8-hydroxy-4,4,7-trimethyl-9-(2-methylpropionyl)-3-(1-methylvinyl)-5beta ...
Zusammenfassung
Bioactivity-guided fractionation of the petroleum ether ext. of the aerial parts of Hypericum papuanum led to the isolation of five new tricyclic phloroglucinol derivs. On the basis of extensive 1D and 2D NMR expts. as well as MS studies, their structures were elucidated as the C-3 epimers of 8-hydroxy-4,4,7-trimethyl-9-(2-methylpropionyl)-3-(1-methylvinyl)-5beta -H-tricyclo[5.3.1.01,5]undec-8-ene-10,11-dione (1, 2); the C-3 epimers of 8-hydroxy-4,4,7-trimethyl-9-(2-methylbutyryl)-3-(1-methylvinyl)-5beta -H-tricyclo[5.3.1.01,5]undec-8-ene-10,11-dione (3, 4), and 8-hydroxy-4,4,7-trimethyl-9-(2-methylpropionyl)-5beta -H-tricyclo[5.3.1.01,5]undec-8-ene-10,11-dione (5), and their corresponding tautomers (1a, 2a, 3a, 4a, 5a). Compds. 1/1a-5/5a were named ialibinones A-E, resp. Compds. 1/1a-4/4a showed antibacterial activity against Bacillus cereus, Staphylococcus epidermidis, and Micrococcus luteus.
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