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Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum

Heilmann, Jörg ; Brun, R. ; Mayr, S. ; Rali, T. ; Sticher, Otto


A new cytotoxic 1,7-dioxa-dispiro[]pentadeca-9,12-dien-11-one deriv., aculeatin D (I), and a new alkenone, 5-hydroxy-hexacos-1-en-3-one , have been isolated as minor compds. from the rhizomes of Amomum aculeatum. Their structures have been detd. mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 ...


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