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Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum

Heilmann, Jörg, Brun, R., Mayr, S., Rali, T. and Sticher, Otto (2001) Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum. Phytochemistry 57 (8), pp. 1281-1285.

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Abstract

A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one deriv., aculeatin D (I), and a new alkenone, 5-hydroxy-hexacos-1-en-3-one , have been isolated as minor compds. from the rhizomes of Amomum aculeatum. Their structures have been detd. mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC50 of 0.38 ...

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Item type:Article
Date:2001
Additional Information (public):CAN 135:301047 11-1 Plant Biochemistry 366477-34-1P; 366477-35-2P (5-Hydroxyhexacos-1-en-3-one) Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxic and antibacterial compds. from Amomum aculeatum)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2001:502703Other
Keywords:New natural products (aculeatin D) Protozoacides (aculeatin D from Amomum aculeatum as) Amomum aculeatum Antibacterial agents Antitumor agents Bacillus cereus Escherichia coli Plasmodium falciparum Staphylococcus epidermidis Trypanosoma brucei Trypanosoma cruzi (cytotoxic and antibacterial compds. from Amomum aculeatum) Molecular structure (of aculeatin D) aculeatin hydroxyhexacosenone Amomum antibacterial antitumor agent
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17194
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