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The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells

Heilmann, Jörg, Wasescha, M. R. and Schmidt, T. J. (2001) The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells. Bioorganic & medicinal chemistry 9 (8), pp. 2189-2194.

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Abstract

The biol. activities of sesquiterpene lactones have been attributed to their reactivity with the cysteine residues of functional proteins forming covalent bonds via Michael type addn. In the present study we investigated the influence of different l-cysteine (cys) and glutathione (GSH) concns. on the cytotoxicity of the sesquiterpene lactones (STLs) helenalin, 11alpha ,13-dihydrohelenalin acetate ...

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Item type:Article
Date:2001
Additional Information (public):CAN 136:266 1-6 Pharmacology 52-90-4 (Cysteine); 70-18-8 (Glutathione) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (glutathione and cysteine levels effect on helenanolide type sesquiterpene lactones cytotoxicity against KB cells); 6754-13-8 (Helenalin); 36505-53-0 (11,13-Dihydrohelenalin acetate); 78853-98-2 (Chamissonolide); 190957-10-9; 374937-03-8; 374937-04-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (glutathione and cysteine levels effect on helenanolide type sesquiterpene lactones cytotoxicity against KB cells)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2001:591202Other
Keywords:Cytotoxic agents Sulfhydryl group (glutathione and cysteine levels effect on helenanolide type sesquiterpene lactones cytotoxicity against KB cells) Sesquiterpenes Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (lactones glutathione and cysteine levels effect on helenanolide type sesquiterpene lactones cytotoxicity against KB cells) glutathione cysteine helenanolide sesquiterpene lactone cytotoxicity thiol
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17195
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