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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Planta medica | ||||
| Verlag: | Thieme | ||||
| Band: | 67 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 5 | ||||
| Seitenbereich: | S. 437-442 | ||||
| Datum: | 2001 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 135:270069 11-1 Plant Biochemistry 57-10-3 (Palmitic acid); 60-33-3 (Linoleic acid); 112-80-1 (Oleic acid) Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea); 80619-02-9 (5-Lipoxygenase); 329967-85-3 (cyclooxygenase-1) Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (inhibition by phenols and polyacetylenes from Atractylodes lancea); 29576-66-7 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 64997-56-4P; 362673-09-4P; 362673-10-7P; 362673-11-8P; 362673-13-0P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 362673-12-9P Role: BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (polyacetylenes from Atractylodes lancea) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Fatty acids Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea) Molecular structure (of phenols and polyacetylenes from Atractylodes lancea) New natural products (phenols and polyacetylenes from Atractylodes lancea) Anti-inflammatory agents Atractylodes lancea (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity) Alkynes Phenols Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phe Antioxidants (phenols and polyacetylenes from Atractylodes lancea as) phenol polyacetylene Atractylodes antiinflammatory agent | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Nein | ||||
| Dokumenten-ID: | 17198 |
Zusammenfassung
From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (I) was isolated as a new natural product. The compd. showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 micro M (5-LOX), 2 micro M (COX-1), 9 micro M (PMN/FMLP), 28 micro M (PMN/OZ)]. ...
Zusammenfassung
From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (I) was isolated as a new natural product. The compd. showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 micro M (5-LOX), 2 micro M (COX-1), 9 micro M (PMN/FMLP), 28 micro M (PMN/OZ)]. Moreover, five new acetylenes were isolated and elucidated as (3Z,5E,11E)-tridecatriene-7,9-diynyl-1-O-(E)-ferulate (II), erythro-(1,3Z,11E)-tridecatriene-7,9-diyne-5,6-diyl diacetate, (1Z)-atractylodin, (1Z)-atractylodinol, (1Z)-acetylatractylodinol plus the known (4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate. Among the acetylenes, only II showed strong inhibition of 5-LOX and COX-1 activity (IC50 (5-LOX) = 3 micro M, IC50 (COX-1) = 1 micro M). In addn., the fatty acids linoleic acid, oleic acid and palmitic acid with previously established 5-LOX-/COX-1 inhibitory actions were identified as major constituents of the n-hexane ext. and thus seem to contribute to the plant's in vitro activity.
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