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Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity

Resch, M., Heilmann, Jörg, Steigel, A. und Bauer, R. (2001) Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta medica 67 (5), S. 437-442.

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Zusammenfassung

From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (I) was isolated as a new natural product. The compd. showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 micro M (5-LOX), 2 micro M (COX-1), 9 micro M (PMN/FMLP), 28 micro M (PMN/OZ)]. ...

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Dokumentenart:Artikel
Datum:2001
Zusätzliche Informationen (Öffentlich):CAN 135:270069 11-1 Plant Biochemistry 57-10-3 (Palmitic acid); 60-33-3 (Linoleic acid); 112-80-1 (Oleic acid) Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea); 80619-02-9 (5-Lipoxygenase); 329967-85-3 (cyclooxygenase-1) Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (inhibition by phenols and polyacetylenes from Atractylodes lancea); 29576-66-7 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 64997-56-4P; 362673-09-4P; 362673-10-7P; 362673-11-8P; 362673-13-0P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 362673-12-9P Role: BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (polyacetylenes from Atractylodes lancea)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2001:546285Andere
Stichwörter / Keywords:Fatty acids Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea) Molecular structure (of phenols and polyacetylenes from Atractylodes lancea) New natural products (phenols and polyacetylenes from Atractylodes lancea) Anti-inflammatory agents Atractylodes lancea (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity) Alkynes Phenols Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phe Antioxidants (phenols and polyacetylenes from Atractylodes lancea as) phenol polyacetylene Atractylodes antiinflammatory agent
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Nein
Eingebracht am:18 Okt 2010 10:53
Zuletzt geändert:08 Mrz 2017 08:27
Dokumenten-ID:17198
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