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Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity

Resch, M. ; Heilmann, Jörg ; Steigel, A. ; Bauer, R.



Abstract

From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (I) was isolated as a new natural product. The compd. showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 micro M (5-LOX), 2 micro M (COX-1), 9 micro M (PMN/FMLP), 28 micro M (PMN/OZ)]. ...

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