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Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity

Resch, M., Heilmann, Jörg, Steigel, A. and Bauer, R. (2001) Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta medica 67 (5), pp. 437-442.

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Abstract

From the rhizomes of Atractylodes lancea, 2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (I) was isolated as a new natural product. The compd. showed strong inhibitory effects on 5-lipoxygenase (5-LOX) and cyclooxygenase-1 (COX-1), but exhibited only weak antioxidative activities [IC50 = 0.1 micro M (5-LOX), 2 micro M (COX-1), 9 micro M (PMN/FMLP), 28 micro M (PMN/OZ)]. ...

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Item type:Article
Date:2001
Additional Information (public):CAN 135:270069 11-1 Plant Biochemistry 57-10-3 (Palmitic acid); 60-33-3 (Linoleic acid); 112-80-1 (Oleic acid) Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea); 80619-02-9 (5-Lipoxygenase); 329967-85-3 (cyclooxygenase-1) Role: BPR (Biological process), BSU (Biological study, unclassified), BIOL (Biological study), PROC (Process) (inhibition by phenols and polyacetylenes from Atractylodes lancea); 29576-66-7 Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 64997-56-4P; 362673-09-4P; 362673-10-7P; 362673-11-8P; 362673-13-0P Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity); 362673-12-9P Role: BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (polyacetylenes from Atractylodes lancea)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2001:546285Other
Keywords:Fatty acids Role: BOC (Biological occurrence), BSU (Biological study, unclassified), BIOL (Biological study), OCCU (Occurrence) (from Atractylodes lancea) Molecular structure (of phenols and polyacetylenes from Atractylodes lancea) New natural products (phenols and polyacetylenes from Atractylodes lancea) Anti-inflammatory agents Atractylodes lancea (phenols and polyacetylenes from Atractylodes lancea and their anti-inflammatory activity) Alkynes Phenols Role: BAC (Biological activity or effector, except adverse), BOC (Biological occurrence), BSU (Biological study, unclassified), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (phe Antioxidants (phenols and polyacetylenes from Atractylodes lancea as) phenol polyacetylene Atractylodes antiinflammatory agent
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17198
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