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New cytotoxic 6,7-cis and 6,7-trans configured guaianolides from Warionia saharae

Hilmi, Fatima ; Sticher, Otto ; Heilmann, Jörg


Using cytotoxicity against the KB cancer cell line (ATCC CCL17) as a lead, bioactivity-guided fractionation of the MeOH-sol. part of the DCM ext. of Warionia saharae leaves led to the isolation of six new cytotoxic guaianolide type sesquiterpene lactones (I-VI). Besides two guaianolides showing the common 6,7-trans fused lactone ring (III and IV), four compds. exhibiting the more rare 6,7-cis ...


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