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Transport of alkamides from Echinacea species through Caco-2 monolayers

Jager, H., Meinel, L., Dietz, B., Lapke, C., Bauer, R., Merkle, H. P. and Heilmann, Jörg (2002) Transport of alkamides from Echinacea species through Caco-2 monolayers. Planta medica 68 (5), pp. 469-471.

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Abstract

To gain more insights into the human intestinal absorption of alkamides from Echinacea species, transport studies were performed with the human adenocarcinoma colonic cell line Caco-2 (ATCC) as a model to assess the epithelial transport of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (1/2), 30 min after apical loading of 25 micro g/mL 1/2, about 15% of these alkamides were detectable on ...

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Item type:Article
Date:2002
Additional Information (public):CAN 138:49348 1-2 Pharmacology 75917-90-7P (2,4,8,10-Dodecatetraenamide, N-(2-methylpropyl)-, (2E,4E,8Z,10E)-); 77448-63-6P Role: PAC (Pharmacological activity), PKT (Pharmacokinetics), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (Echinacea alkamides transport through Caco-2 cells and cytotoxicity:insight into human intestinal absorption)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2002:468677Other
Keywords:Animal cell line (Caco-2 Echinacea alkamides transport through Caco-2 cells and cytotoxicity:insight into human intestinal absorption) Cytotoxic agents Echinacea atrorubens Human Intestine Pharmacokinetics (Echinacea alkamides transport through Caco-2 cells and cytotoxicity:insight into human intestinal absorption) Amides Role: PKT (Pharmacokinetics), BIOL (Biological study) (Echinacea alkamides transport through Caco-2 cells and cytotoxicity:insight into human intestinal absorption) Echinacea alkamide transport Caco2 human intestinal absorption
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17204
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