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Transport of alkamides from Echinacea species through Caco-2 monolayers

Jager, H. ; Meinel, L. ; Dietz, B. ; Lapke, C. ; Bauer, R. ; Merkle, H. P. ; Heilmann, Jörg



Abstract

To gain more insights into the human intestinal absorption of alkamides from Echinacea species, transport studies were performed with the human adenocarcinoma colonic cell line Caco-2 (ATCC) as a model to assess the epithelial transport of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (1/2), 30 min after apical loading of 25 micro g/mL 1/2, about 15% of these alkamides were detectable on ...

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