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Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells

Gertsch, Jurg, Guttinger, Martin, Heilmann, Jörg and Sticher, Otto (2003) Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells. Bioorganic & medicinal chemistry 11 (6), pp. 1057-1063.

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Abstract

Curcumin, the yellow pigment of the rhizome of Curcuma longa is known to inhibit the transcription factors AP-1, Egr-1, NF-kB, c-myc and several important signaling kinases. We therefore investigated the differential effects of curcumin in concn. between 1.5 and 13.6 micro M on gene expression in T Jurkat CD4+ and human peripheral blood mononuclear cells (PBMCs). Relative quantification with ...

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Item type:Article
Date:2003
Additional Information (public):CAN 139:95045 1-7 Pharmacology 10102-43-9 (Nitric oxide); 83869-56-1 (Granulocyte-macrophage colony-stimulating factor) Role: BSU (Biological study, unclassified), BIOL (Biological study) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells); 458-37-7 (Curcumin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2003:144134Other
Keywords:Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1 curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Antitumor agents CD4-positive T cell Human Mononuclear cell (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Gene Interleukin 2 Interleukin 6 mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Interferons Role: BSU (Biological study, unclassified), BIOL (Biological study) (gamma curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) curcumin mRNA lymphocyte monocyte gene antitumor
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17211
Owner only: item control page
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