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Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells

Gertsch, Jurg, Guttinger, Martin, Heilmann, Jörg und Sticher, Otto (2003) Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells. Bioorganic & medicinal chemistry 11 (6), S. 1057-1063.

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Zusammenfassung

Curcumin, the yellow pigment of the rhizome of Curcuma longa is known to inhibit the transcription factors AP-1, Egr-1, NF-kB, c-myc and several important signaling kinases. We therefore investigated the differential effects of curcumin in concn. between 1.5 and 13.6 micro M on gene expression in T Jurkat CD4+ and human peripheral blood mononuclear cells (PBMCs). Relative quantification with ...

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Dokumentenart:Artikel
Datum:2003
Zusätzliche Informationen (Öffentlich):CAN 139:95045 1-7 Pharmacology 10102-43-9 (Nitric oxide); 83869-56-1 (Granulocyte-macrophage colony-stimulating factor) Role: BSU (Biological study, unclassified), BIOL (Biological study) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells); 458-37-7 (Curcumin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2003:144134Andere
Stichwörter / Keywords:Cyclins Role: BSU (Biological study, unclassified), BIOL (Biological study) (D1 curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Antitumor agents CD4-positive T cell Human Mononuclear cell (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Gene Interleukin 2 Interleukin 6 mRNA Role: BSU (Biological study, unclassified), BIOL (Biological study) (curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) Interferons Role: BSU (Biological study, unclassified), BIOL (Biological study) (gamma curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells) curcumin mRNA lymphocyte monocyte gene antitumor
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Nein
Eingebracht am:18 Okt 2010 12:26
Zuletzt geändert:08 Mrz 2017 08:27
Dokumenten-ID:17211
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