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Curcumin differentially modulates mRNA profiles in Jurkat T and human peripheral blood mononuclear cells

Gertsch, Jurg ; Guttinger, Martin ; Heilmann, Jörg ; Sticher, Otto



Abstract

Curcumin, the yellow pigment of the rhizome of Curcuma longa is known to inhibit the transcription factors AP-1, Egr-1, NF-kB, c-myc and several important signaling kinases. We therefore investigated the differential effects of curcumin in concn. between 1.5 and 13.6 micro M on gene expression in T Jurkat CD4+ and human peripheral blood mononuclear cells (PBMCs). Relative quantification with ...

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